Migraine Pagemany migraine preventatives no better than placebo
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many migraine preventatives no better than placebo
charmed quark Thu Jun 20, 2013 4:30 am
Another meta-analysis of standard migraine preventatives. I've taken all of these with minimal to no effect:
"The review is based on 215 randomized controlled trials with 59 drugs. There were 9 trials on topiramate, 3 on valproic acid, 4 each on propranolol and metoprolol, 3 on timolol, and 1 each on angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers.
The most important message here is that there are basically no differences in efficacy between these drugs and placebo. "
http://www.medscape.com/viewarticle/805338?nlid=31744_1521&src=wnl_edit_medp_wir&uac=142709SZ&spon=17
"The review is based on 215 randomized controlled trials with 59 drugs. There were 9 trials on topiramate, 3 on valproic acid, 4 each on propranolol and metoprolol, 3 on timolol, and 1 each on angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers.
The most important message here is that there are basically no differences in efficacy between these drugs and placebo. "
http://www.medscape.com/viewarticle/805338?nlid=31744_1521&src=wnl_edit_medp_wir&uac=142709SZ&spon=17
- Shamliyan TA, Choi JY, Ramakrishnan R, et al. Preventive pharmacologic treatments for episodic migraine in adults. J Gen Intern Med. 2013 Apr 17. [Epub ahead of print]
charmed quark- Posts : 273
Join date : 2009-12-23
Re: many migraine preventatives no better than placebo
charmed quark Thu Jun 20, 2013 4:36 am
The medscape article may have mis-interpreted the metastudy. The abstract of the article in http://www.ncbi.nlm.nih.gov/pubmed/22529202 says:
"The author panel reviewed 284 abstracts, which ultimately yielded 29 Class I or Class II articles that are reviewed herein. Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol are effective for migraine prevention and should be offered to patients with migraine to reduce migraine attack frequency and severity (Level A). Frovatriptan is effective for prevention of menstrual migraine (Level A). Lamotrigine is ineffective for migraine prevention (Level A)."
"The author panel reviewed 284 abstracts, which ultimately yielded 29 Class I or Class II articles that are reviewed herein. Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol are effective for migraine prevention and should be offered to patients with migraine to reduce migraine attack frequency and severity (Level A). Frovatriptan is effective for prevention of menstrual migraine (Level A). Lamotrigine is ineffective for migraine prevention (Level A)."
charmed quark- Posts : 273
Join date : 2009-12-23
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