technical help please

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technical help please

Post  marion on Tue Feb 23, 2010 9:48 pm

Last year I was diagnoised with euthyroid hashimotos. ie the thyroid is being eaten by one sort of antibodies but still putting out "normal" levels of hormone tsh.

Today test results back for immunoglobulin IgE at 3840 kU/L (0-100normal). So allergy anti-bodies really high. Dust mites and animals come back as "low" allergens.

My medical knowledge is zip. Doctor just said go on anti-histomines and clean your house. Does anyone know if there's a correlation here? To my feeble brain antibodies are antibodies.

Tried the web but can't seem to get anywhere. Any info appreciated.
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marion

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Re: technical help please

Post  Hal on Tue Feb 23, 2010 10:22 pm

Haven't a clue as to what that is, but I think I would get a second opinion from a doctor that specializes in Thyroid problems. And I would do it quickly.

Hal
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Re: technical help please

Post  Mule Kick on Wed Feb 24, 2010 3:12 am

marion,

Have you read Living Well With Hypothroidism by Mary J. Shomon, published by Harper Collins? It covers Hashimoto's thyroiditis among other topics.

TSH or "Thyroid-stimulating hormone is released into the bloodstream by the pituitary gland, to tell your thyroid to release more thyroid hormone." page 10.

Euthyroid (pronounced YOU-thyroid) is when the THS levels fall within the normal range.
"Values below the lower range can indicate hyperthyroidism, an overactive thyroid. Values above the top range indicate hypothyroidism, an underactive thyroid. The higher the number, the more hypothyroid you are, and therefore the less functional your thyroid is considered to be." page 10.
{Emphasis in both above quotes is mine.}

"The thyroid's main purpose is to produce, store, and release two key thyroid hormones, triiodothyronine (T3) and thyroxine (T4)." page 4. "Released thyroid hormones move into the bloodstream, carried by a plasma protein known as thyroxine-binding globulin (TBG)." page 6. "Thyroid hormones control metabolim -- the process by which oxygen and calories are converted to energy for use by cells and organs." page 5.

"In primary hypothyroidism, the thyroid itself doesn't work properly for a variety of reasons. Hypothyroidism most commonly results from the autoimune disease Hashimoto's thyroiditis. Hashimoto's disease results when antibodies attach themselves to proteins in the thyroid tissue. The attachment process is a declaration of war to the rest of the immune system, and the thyroid is then invaded by immune cells that progressively destroy the hormone-producing thyroid tissue in a misguided effort to fend off the percieved invader." page 8.

"One point of confusion that it's important to clarify: 'Hashimoto's' and 'hypothyroidism' are not interchangeable terms. Hashimoto's is a disease. Hypothyroidism is a condition. Hashimoto's is an autoimmune disease that usually causes people eventually to become hypothroid. Hypothyroidism is a condition that can result from a number of causes and diseases." page 8.
{Emphasis in both above quotes is mine.}

To answer your question, different antibodies attack different organs or tissues. The presence of anti-thyroid antibodies often indicates Hashimoto's disease, while the presence of other antibodies could indicate other autoimmune diseases. For example antibodies to the bacteria Klebsiella pneumonae can cause Ankylosing Spondylitis.

"There is a strong relationship between bacteria known as Yersinia enterocolitica infection, and Hashimoto's thyroiditis. Yersinia bacteria are found in the fecal matter of livestock and domesticated and wild animals." pages 36 and 37.

"Chronic headaches and migraines can be symptoms of hypothyroidism." page 66.
{Emphasis in above quote is mine.}

I hope this helps.

I have multi-nodular goiter. For now, we are just doing watchful waiting.
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Re: technical help please

Post  marion on Wed Feb 24, 2010 4:02 pm

Thanks Mule Kick and Hal. It's interesting the point you raise about the bacteria from animals causing the Hashimoto's as animals are appartently one of my allergens.
The whole situation is becoming so confusing. I am trying now to relate back to migraine attacks and feeling lousy attacks as to whether they are some sort of anaphylactic reaction.
I am still going round in circles as I have been for the last twenty years, but the last six months having received two positive blood tests to something (rather than no there's nothing wrong with you) has meant the circles are getting smaller - I think.
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Re: technical help please

Post  Mule Kick on Wed Feb 24, 2010 6:16 pm

The entry for Immunoglobulins in The American Medical Association Home Medical Encyclopedia, pages 575 and576, reads:

Proteins found in the blood serum and in tissue fluids, also known as antibodies. Immunoglobulins are produced by cells of the immune system called B-lymphocytes. their function is to bind to substances in the body that are regognized as foreign antigens (often proteins on the surface of bacteria and viruses). This binding is a crucial event in the destruction of the microorganisms that bear the antigens. Immunoglogulins also play a central role in allergies and hypersensitivity reactions. In this case they bind to antigens that are not necessarily a threat to health, which may provoke an inflammatory reaction.

There are five classes of immunoglobulins; of these immunoglobulin G (IgG) is the major immunoglobulin in human blood serum. The IgG molecule consists of two parts, one of which binds to antigen; the other binds to other cells of the immune system. These other cells are principally white cells called phagocytes, which then engulf the microorganisms bearing the antigen. The antigen-binding site of the IgG molecule is variable in its structure, the different versions of the molecule being capable of binding to an almost infinite number of antigens.

Immunoglobulins can be extracted from blood of recovering patients and used for passive immunization against certain infectious diseases.

{Bold added by me for emphasis.}
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Re: technical help please

Post  marion on Wed Feb 24, 2010 9:33 pm

So in theory does that mean that the body could decide that the thyroid is the allergen? and decide to attack it with immunoglobulins.

From what I can find though science has linked the presence of Graves and raised immunoglobulins within individuals, but I can't find any science that links the two as a cause and effect event.
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