New migraine preventative drugs

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New migraine preventative drugs

Post  Migrainegirl on Sat Jul 05, 2014 9:13 am

They are apparently making good progress on new drugs that specifically target migraines (as opposed to most preventatives which were all developed for other diseases).   Maybe 5 years out to hit the market. I guess it's something...

http://www.medscape.com/viewarticle/827838


Last edited by Migrainegirl on Sat Jul 05, 2014 4:22 pm; edited 1 time in total (Reason for editing : Corrected link)
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Re: New migraine preventative drugs

Post  Seaine on Sat Jul 05, 2014 2:47 pm

That link looks like it's the study on cholic and migraines
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Re: New migraine preventative drugs

Post  Migrainegirl on Sat Jul 05, 2014 4:23 pm

Link corrected. Sorry for the confusion.

http://www.medscape.com/viewarticle/827838
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Re: New migraine preventative drugs

Post  Sara79 on Sun Jul 06, 2014 7:35 am

Would someone be willing to quote part/all of this? I'm too tired/aura-y to want to create an account right now, but would love to see even the synopsis, if someone's willing.

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Re: New migraine preventative drugs

Post  Seaine on Sun Jul 06, 2014 5:10 pm

Sure thing.  The basic points are:

1.  Something called the "calcitonin gene-related peptide" has been shown to increase during migraine attacks and decreases again once the migraine is over.

2.  The possible drugs would involve antibodies, in other words they would attack the CGRP pathway meaning a decrease in CGRP.

3.  It will be at least 5 years before any drug of this nature will be approved by the FDA.

4.  This would be the first medication(s) developed to prevent migraines.  As migrainegirl said, all other preventatives were actually made for other conditions, hence their poor success rate.

5.  There seem to be several drugs in the works.  Some mop up excess CGRP and some bind to the receptor disabling it.

6.  Trials so far show that patients receiving the real drug were more likely to have fewer migraines versus those receiving a placebo... notably, 41% receiving the real drug had a 100% reduction in migraines after 9 weeks, versus 17% of the placebo takers.  There are other trials mentioned as well.  All trials successfully showed that the real drug worked better than a placebo.

7.  Adverse events reported were upper respiratory tract infections, injection site pain, neck pain, abdominal pain, dizziness, injection site erythema, rash, hypertension, and pain in extremities, although it doesn't say how common the adverse events were.
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Re: New migraine preventative drugs

Post  Sara79 on Mon Jul 07, 2014 4:36 am

Thank you!

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Another prevention study ongoing

Post  dxsin on Sat Aug 09, 2014 3:30 pm

See also this thread: Study about migraine prevention with Acetium
This preparation is already available, however not yet intended for migraine prevention. It is not a drug. It's classified as medical device.

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