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Gepants...a new migraine treatment...

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Post  living Sat Apr 09, 2011 4:27 am

So I was just reading this journal article and came across a reference to 'gepants'. Never heard of em. I'm gonna go digging. Have you guys heard of em?

The Extracranial Vascular Theory of Migraine—A Great Story Confirmed by the Facts
HEADACHE: THE JOURNAL OF HEAD AND FACE PAIN
Volume 51, Issue 3, March 2011, Pages: 409–417, Elliot Shevel
Article first published online : 25 FEB 2011, DOI: 10.1111/j.1526-4610.2011.01844.x
AbstractFull Article (HTML)PDF(173K)References

SUMMARY
That vasodilatation is an important factor in
migraine is demonstrated by the fact that the most
widely used migraine rescue medications, the ergots
and the triptans, and the most promising of the newer
drugs, the gepants, possess one significant common
denominator: they all potently constrict abnormally
dilated extracranial arteries while simultaneously
reducing or eliminating migraine pain. Furthermore,
to date all migraine-provoking agents have had
vasodilating properties

living

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Post  Anna's Mom Sat Apr 09, 2011 6:21 am

I was curious and found this:

http://updates.pain-topics.org/2011/03/source-of-migraine-pain-superficial.html
Anna's Mom
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Post  Anna's Mom Sat Apr 09, 2011 8:00 am

Ali, have you see this:

http://en.wikipedia.org/wiki/Migraine_surgery

You are listed at the bottom under additional references.
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Post  living Sat Apr 09, 2011 8:44 am

Dr Sultaneh - thank you so much for your work creating surgical cures for migraine sufferers and discovering the mechanical causes of this horrible pain. Your work is so valuable to us who suffer from migraine. I can't imagine how frustrating it must be to have your life's work go unacknowledged, though. I am really sorry to hear that your work has not been acknowledged properly. But Shevel's is only one paper - perhaps there are other papers which do acknowledge your work? Shevel has acknowledged a bunch of research that didn't have as much statistical power as your study which had 1224 patients . Perhaps you can publish some findings in one of these journals? I didn't have access to those links so I couldn't read the ones you posted.



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Post  living Sat Apr 09, 2011 8:55 am

Also Dr Ali, when you cut those arteries, why doesn't it make parts of the face die? Do these blood supplies grow back or something?

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Post  Guest Sat Apr 09, 2011 10:26 am

click on "why do practitioners dislike chrnic pain patients" on anna's mom's first link.

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